ALS/MND
ALS is that both of
upper neuron and lower neuron are violated and the beggining is almost to
progress in the non-symmetry from the end of the upper limbs or bottom
legs.
In other words, a difficulty is caught, and only the nerve that a
movement is administered doesn't have other senses and an autonomy nerve
violated selectively.
The abnomality of the bottom legs tendon reflection and
so on is presumed muscle power decline muscle atrophy, muscle convergence
beginning upper neuron violate as a symptom.
As a type,
- The upper limbs type.
- The bottom legs type.
- Bulbar Onset type.
It varies when it is divided into three and for
example even the upper limbs type started from the right hand and progresses in
left hand like me, and the other to the right foot.
It is being called type M
pattern /N pattern/reverse N by the progressive form voice.
There is a case
of progress speed that breathing muscle is violated fast rather than it
progresses like me in bottom leg, if there is a person who can live even if
there is a difference very much and a ventilator is put no more than how many
years, too.
But, average 5 years and more
existence rates are only less than 20%.
Respirator installation is rejected how, and this numerical value shows
whether there are many ones which death is chosen than.
Why is it?
As for ALS, the patient, who attached a ventilator between
these 2 and a half years, non-choice patients are 'five people' with a 'two
persons' even in the hospital which a fact I am in.
A face is made
a soil color in the
dyspnea and the end, and consciousness meets death with the little memory due to
the carbonic increase and an oxygen shortage , too.
It is the reality of the
dignity death.
Why?
ALS Amyotrophic Lateral Sclerosis and the treatment
front.
'The research of sicking cause'.
- SOD-1 gene. The meaning that the ALS getting sick mouse which can be
limited now as a cause of ALS and which can be only tested again can be
provided is big.
SOD (SuperOxideDesmutase) is the enzyme which controls
strong active oxygen O2-(Superoxide). It is here in the inside of the body
when they are active oxygen such as O2-/H2O2/OH/Single oxigen and a balance of
the enzyme which anti-working to them and Beta calotin(vitamin A)/vitamin C.
One itself is defended by the strong sterilization action of this O2- in the
human inside of the body from the foreign invader.
For example, active
oxygen occurs, and an organization difficulty is caused after when it has
emptiness blood for the thing after the heart body outside circulation and the
liver transplant. And, activated oxygen is brought about even if it depends on
the keen stress. It is doubting the participation of the leukocyte in
activated oxygen.
That is the reason of the possibility that ALS is the
self immune desease.
However, there is an unusual (function decline) in
this SOD function, and moreover 2% of the patients of ALS know that it is a
family type (heredity). Family type /FALS is said as about 10%- within 15% of
whole ALS.
- The ninth chromosome.
There is existence of the special family line
that a wrong point is unusually found to the ninth chromosome in the family
type ALS. ALS occurs frequently in the family line as much as to be
unusual.
- Gultamate.
At Johns Hopkins, the reason why the Gultamate increase in
the brain and spinal area is that when mRNA copy and produce EAAT2 PROTAIN
occure the mistake of the code and make strange EAAT2. So that EAAT2 can not
inhibit the Gultamate that injure the nerve. It was in deed found in 65% of
ALS patients and not found in the other desease.
- As for the getting sick cause?
It is
abundant in the southern part of ( Wakayama/Mie Pref.) from the viewpoint of
area, and there is a scholar who advocates aluminum opinion, too.
There is
a person complaining about it to make it call attention in Amargum (mercury)
opinion in the case of treatment for dentistry and the agricultural chemicals
environment material again in the United States, too. And, even if it seems
that poliovirus cured it , there is a scholar who announces the enteroviruses
opinion from setting up sometimes muscle atrophy after over 10 years, too.
There is a scholar who proposes lyme disease cause opinion again, too, and it
is very much in confusion.
The fact which many married couples getting ALS
who is a wife or a husband ( the "infection" ) isn't seen though it seems to
support a virus opinion from the report in the one which is ALS with the
family who doesn't have a blood relation, and the married couple, too. Aren't
you strange even if ALSs, the patient, increase more with Amargum of treatment
for dentistry?
It thinks about a traffic accident, head blow due to the
fall and so on and an influence by the operation, too. And, it doubts blood
way deficiency in the brain by heavy smoking, too.
But, it is a fact that
all is poor in a conclusive evidence like this.
There is an erroneous
diagnosis, too, and it is the ill effect of cause specifying because る
diagnosis inspection that an ALS diagnosis was done with the elimination and
which the final diagnosis isn't decided in it.
And, it may not be sick in
one cause. And, a cause may vary even if ALS is said.
Cooperate
with the << questionnaire >>
<< The knowledge about various matters of DNA and RNA
>>
There is DNA of top of the
chromosome with the abbreviation of deokisiribo nuclear acid. There is tidy
law of form that it consisted of only AGTC four basic combinations by spiral
shape.
A (adenin) becomes a pair only with G (guanin), and T (timin)
becomes a pair only with C (citocin). In other words, let's imagine the thing
which the combination of G-A, T-C, C-T, A-G rivaled in spiral
stairs.@@@@
When it is reproduced, the chain of the pair is cut with the
enzyme, and it becomes one. Base arrangement is copied properly by
transfer(transcription) RNA. Like (CATTGAATTTCAGTAA). Because the base of each
pair is decided, an opposition side becomes necessary with (TGCCAGGCCCTGACGG).
What is it rational with?!!
Only specific protain is refined by messenger
RNA by a certain base arrangement. But, when it is reproduced by accident with
G->A, false protain is made at the grade. The bases which originally are
supposed to become a pair and not to have stick, and distortion occurs in the
chain of the pair, and a case such as a cancer creates cancer protain, too,
and various accidents are made.
'The research of the treatment medicine'.
- Gultamate repression medicine.
Rilutek./Neurontin.
- Immunity repression medicine.
Sanofi.
- nerve protection material./nerve growth factor.
GDNF./FK506
- Anti-oxidizer.
Soybeen Resitin combination SOD.(anti O2-).
Seren
anti-oxidunt coctails.(anti H2O2).
- Other methods only for trial.
Lymphoplasma pheresis.
Fetal
stem-cell transplantation.
<<
The publications of ALS occation.>>
"The
days of writing using her
blink."
Writtend
by Mr. Doi and Mrs. Kikuko Doi,publshed by Hakusuisha, 1800 yen.
"The
communication instruments for the disability persons."
Writtend and
published by Tokyo vivid life center. 300 yen.
"The Blinkof my
life-still my eye blow can move." Writtend by Mr. Ikuo Higasimitateda.
Published by Toyo Economical Shinposha. 1800 yen.